Located at the Karlsruhe Institute of Technology (KIT)
Miha Modic has been a tenure-track professor at Center SynGen Karlshruhe since 2025.
Interests: RNA-protein interaction networks, synthetic genomics & genome engineering, deep learning for RNA function prediction, programmable RNA tools, spatial RNA biology, stem cells, and early development & embryonic gene regulation
Research
Gene Regulation
The Modic group aims to decode the intricate principles and networks of cross-regulatory interactions between RNAs and proteins that govern gene expression.
RNA-Protein & RNA-RNA Networks
Most RNA-binding proteins regulate hundreds of RNAs, while each mRNA interacts with numerous RBPs. The Modic Lab examine these complex interactions at the network level to decipher regulatory pathways.
Synthetic Genomics
The Modic Lab study how cells decide which direction to take during development and what roles RNA molecules play in the complex process of embryogenesis.
Bioinformatics & Machine Learning
The Modic Lab develop and apply machine learning methods and bioinformatic tools tailored specifically to RNA biology and genomics to uncover novel functions of RNA molecules.
Decoding and Re-engineering the RNA Coordinate System
The Modic Lab are uncovering the principles of embryonic development and unraveling the secrets of RNA with its complex transcriptome networks. Harnessing the power of integrative approaches, they employ cutting-edge tools from functional RNA biology, synthetic genomics, bioinformatics, and machine learning to drive our discoveries forward using stem cells and synthetic embryo-like model systems.
Group
The Modic Lab collaborates with the following Center SynGen research groups and members' groups:
-
Dr. Alexander Sasse
-
Prof. Dr. Sylvia Erhardt
-
Prof. Dr. Lennart Hilbert
- Kristin Straub, lab manager (KIT)
- Jona Novljan, PhD Student (KIT and NIC)
- Jure Rebselj, PhD Student (KIT)
- Saurabh Dey, PhD Student (KIT)
- Jannis Kaiber, MSc Student (KIT)
- Maksimiljan Adamek, PhD Student (NIC)
- Tajda Klobučar, Postdoc (NIC)
- Anja Trupej, PhD Student (NIC)
- Nina Oven, MSc Student (NIC)
- Dominik Rihar, MSc Student (NIC)
Center SynGen Collaborations
The Modic Lab collaborates with the following Center SynGen research groups and members' groups:
-
Dr. Alexander Sasse
-
Prof. Dr. Sylvia Erhardt
-
Prof. Dr. Lennart Hilbert