​The project will combine systems biology, bioengineering, and synthetic genomics approaches, along with quantitative cell biology and biochemical techniques, to develop and interrogate biological design principles across eukaryotic systems. A central goal is to use yeast as a genetically tractable model system, followed by work in mammalian models, to establish concepts and tools that can be extended toward translational applications and, in the longer term, gene-therapy-oriented strategies.

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We seek highly motivated, creative, and collaborative candidates with a strong background in molecular biology, preferably complemented by experience in one or more of the following areas:

• yeast genetics and/or yeast cell biology

• systems biology or quantitative biology, preferably using yeast

• genome engineering/synthetic biology, yeast and/or mammalian

• cell biology, microscopy, and biochemical approaches

• functional genomics and computational data analysis, including AI

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The positions are particularly well suited for applicants who are excited to work at the interface of fundamental molecular cell biology and biological engineering, and who are interested in using their fundamental knowledge in basic cell function to engage creative new concepts of biological engineering to translate mechanistic insight from model organisms, in particular yeast, into more complex cellular systems.
 

Successful candidates will join a highly interactive research environment at ZMBH. They will work within a collaborative setting that bridges all levels, from fundamental molecular biology to clinical applications.

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Candidates should hold a PhD in molecular biology, cell biology, biochemistry, genetics, bioengineering, or a related discipline by the start date. Evidence of scientific productivity, independence, and enthusiasm for interdisciplinary research is expected. Excellent communication skills in English are required.

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This job is part of an Advanced Research + Invention Agency-funded project, subject to contract negotiations.

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To apply, please send:

• a cover letter outlining research interests and motivation

• a curriculum vitae

• a summary of previous research achievements

• contact details for 2-3 referees​
   

Location: ZMBH, Heidelberg University, Heidelberg, Germany

Start date: negotiable, as early as June 2026 is possible

Duration: fixed-term, minimum 2 years, with details to be specified according to funding and university regulations

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Applications should be sent in one PDF file by email to Center SynGen (office-syngen@zmbh.uni-heidelberg.de) on behalf of Nora Vögtle and Michael Knop.   

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Applications will be considered until the positions are filled.

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Heidelberg University stands for equal opportunities and diversity. Persons with severe disabilities will be given preference if they are equally qualified. Information on job advertisements and the collection of personal data is available at http://www.uni-heidelberg.de/en/job-market.